{beta}-Cell-Specific Ablation of the Hepatocyte Growth Factor Receptor Results in Reduced Islet Size, Impaired Insulin Secretion, and Glucose Intolerance -- Dai et al. 167 (2): 429 -- American Journal of Pathology

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{beta}-Cell-Specific Ablation of the Hepatocyte Growth Factor Receptor Results in Reduced Islet Size, Impaired Insulin Secretion, and Glucose Intolerance -- Dai et al. 167 (2): 429 -- American Journal of Pathology 29/7/2005

This Article Services PubMed ( American Journal of Pathology. 2005;167:429-436.) © 2005 ß-Cell-Specific Ablation of the Hepatocyte Growth Factor Receptor Results in Reduced Islet Size, Impaired Insulin Secretion, and Glucose Intolerance Chunsun Dai *, Chang-Goo Huh , Snorri S. Thorgeirsson and Youhua Liu * From the Department of Pathology, * University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland Hepatocyte growth factor (HGF) and its c-met receptor consist of a paired signaling system that has been implicated in the regulation of pancreatic ß-cell survival, proliferation, and function. To define the role of HGF/c-met signaling in ß-cell biology in vivo , we have generated c

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